Do seeds disable Unlocks Isaac?
"Any and all seeds disable achievements and unlockables, so do not use if you plan to make a serious run."
Except for some special seeds, inputting a seed will cause the 'no trophies' mark to appear. This prevents any achievements from being obtained on that particular run. Special seeds do not affect level generation.
Start a new run (it cannot be a seeded run) and get moving. You'll need to defeat the boss of the first floor within one minute. You'll immediately know if you've succeeded, as Mom will start yelling at you. Bomb any spot in the starting room and you'll be rewarded with half of the Broken Shovel.
The Binding of Isaac: Rebirth contain seeds, which affect all the decisions made in the game. Putting in seeds manually will ensure that the player gets the same exact levels for that seed every single time. For example, two different people using the same seed will get the same enemies, items, and level layouts.
You can't use seeded runs to get unlocks. Don't take damage. Consider visiting the shop if you have a spare key and 5 cents for a spirit heart.
If you can unlock 12 characters in platformer roguelike Spelunky 2 (on top of the four you start with), then you will also unlock seeded runs. A seeded run lets you type in an eight character code from a limited selection of letters and numbers, and play the set of procedurally generated levels that follow.
Every single achievement that you can unlock for doing something specifically in a run requires the player to be in a non-seeded run.
In Afterbirth+ and Repentance, having any enabled mod will disable the ability to unlock any achievements to encourage new players to play the game without any. To enable unlocking achievements with mods enabled, you need to defeat Mom at least once with all of your mods disabled.
1) Stronghold and Ruined Portal
For players looking for easy access to both the Nether and The End, this seed has a Stronghold and a Ruined Portal right within 1000 blocks of spawn. They can complete multiple achievements such as The End? for entering The End and the achievement The End for killing the Ender Dragon.
- First, start a new unseeded run as any character. Defeat the first floor's boss within 1 minute. ...
- Next, clear Boss Rush. This will grant the second piece of the Broken Shovel, completing. ...
- Finally, a single Grave Room with a dirt patch in its center will appear in the. Dark Room.
Who is the best character to use to unlock the forgotten?
Out of all the characters in the game, Azazel is probably the best choice. He doesn't start with any heart containers (instead getting 3 Black Hearts,) but he moves fast, flies, and can do good damage with his short-range Brimstone attack.
Enabling unlocks
In Afterbirth+ and Repentance, having any enabled mod will disable the ability to unlock any achievements to encourage new players to play the game without any. To enable unlocking achievements with mods enabled, you need to defeat Mom at least once with all of your mods disabled.

5 years. It took you 5 years. Thats not true, you can unlock the lost with seeds, like a seed with a room that has boomlings, or a cave after the boss! Note that the actual unlock only happens on the 4th step of the unlock process, which must be done without a seed.
Yes. You can use the console however you want and unlock things / get achievements, as long as you use it after unlocking the Womb on that save. You can't trigger achievements directly with the console on Repentance because the "achievement" command has been removed and only exists on AB+.